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Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

Ranhua JIANG, Zhibo HAN, Guangsheng ZHUO, Xiaodan QU, Xue LI, Xin WANG, Yuankang SHAO, Shimin YANG, Zhong Chao HAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 94-100 doi: 10.1007/s11684-011-0116-z

Abstract: Bone marrow is the traditional source of human MSC, but human term placenta appears to be an alternativeHere, the therapeutic effect of human placenta-derived MSC (PD-MSC) was studied in type 2 diabetes patients

Keywords： placenta stem cells     treatment of type 2 diabetes    

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New medical risks affecting obstetrics after implementation of the two-child policy in China

Qiang Li, Dongrui Deng

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 570-575 doi: 10.1007/s11684-017-0552-5

Abstract: rates of infertility, spontaneous abortion, fetal malformation, gestational diabetes, cesarean section, placenta

Keywords： two-child policy     birth defects     cesarean delivery     placenta previa    

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Comparison of birth weight and umbilical and placental characteristics of cloned and artificial insemination-derived piglets

Zheng AO, Chengfa ZHAO, Yanmin GAN, Xiao WU, Junsong SHI, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Zicong LI

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 54-60 doi: 10.15302/J-FASE-2018249

Abstract: question whether the low survival rate of SCNT piglets was related to birth weight, umbilical cord or placentaThus, the low survival rate of SCNT piglets may be associated with abnormal umbilical cord and placenta

Keywords： cloned     pig     death     placenta     SCNT     umbilical cord    

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SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal–Fetal Interface Article

Wei Chen, Peng Yuan, Ming Yang, Zhiqiang Yan, Siming Kong, Jie Yan, Xixi Liu, Yidong Chen, Jie Qiao, Liying Yan

Engineering 2020, Volume 6, Issue 10,   Pages 1162-1169 doi: 10.1016/j.eng.2020.07.013

Abstract:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world, leading to large-scale population infection. Angiotensin-converting enzyme 2 (ACE2) is the receptor of both severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2. However, it is still controversial whether vertical transmission exists. In order to investigate the potential risk of SARS-CoV-2 vertical transmission, we explored ACE2 and TMPRSS2 expression patterns in peri-implantation embryos and the maternal–fetal interface using previously published single-cell transcriptome data. The results show that day 6 (D6) trophectoderm cells (TE) in peri-implantation embryos, as well as 8-week syncytiotrophoblast (STB_8W) cells and 24-week extravillous trophoblast (EVTs_24W) cells in the maternal–fetal interface, strongly co-expressed ACE2 and TMPRSS2, indicating SARS-CoV-2 infection susceptibility. The ACE2-positive-expressing cells in the three cell types mentioned above share common characteristics, which are involved in autophagy and immune-related processes. ACE2 showed no gender bias in post-implantation embryos but showed a significant gender difference in D6 TE, D6 primitive endoderms (PE), and ACE2 positive-expressing STB cells. These findings indicate that there may be different SARS-CoV-2 infection susceptibilities of D6 embryos of different genders and during the gestation of different genders. Our results reveal potential SARS-CoV-2 infection risks during embryo transfer, peri-implantation embryo development, and gestation.

Keywords： SARS-CoV-2     ACE2     Vertical transmission     Placenta     Peri-implantation    

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Title Author Date Type Operation

Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

Ranhua JIANG, Zhibo HAN, Guangsheng ZHUO, Xiaodan QU, Xue LI, Xin WANG, Yuankang SHAO, Shimin YANG, Zhong Chao HAN

Journal Article

New medical risks affecting obstetrics after implementation of the two-child policy in China

Qiang Li, Dongrui Deng

Journal Article

Comparison of birth weight and umbilical and placental characteristics of cloned and artificial insemination-derived piglets

Zheng AO, Chengfa ZHAO, Yanmin GAN, Xiao WU, Junsong SHI, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Zicong LI

Journal Article

SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal–Fetal Interface

Wei Chen, Peng Yuan, Ming Yang, Zhiqiang Yan, Siming Kong, Jie Yan, Xixi Liu, Yidong Chen, Jie Qiao, Liying Yan

Journal Article